Frontera Insight -No.02

NO.02

General Issue No. 2

https://www.fronteratherapeutics.com/

FRONTERA

INSIGHT

● Innovation

● Efficient

● Integrity

● Rigorous

We have worked hard in the past two years under extremely difficult circumstances.

Working around the clock, relaying work and giving our best effort.

I am touched by everyone working releatlessly toward company goal.

Today, we are facing even greater internal and external pressure.

Only when the speed of our own growth is outpaces the speed of external changes.

We can be worthy of ourselves and full motivated to challenge more unknowns.

I have full confidence in you and in the company.

I believe that you have that too.

How fortunate we are to see that our efforts have started to benefit patients.

Although no miracle has happened yet, the qualiity of their lives has improved significantly.

Every time I think of this, it makes me teary-eyed and excited.

This is the aspiration and goal we strive for.

Thank you for the energy that each of you brings everyday.

Keep going!

cONTENTS

Science Class

. Small Tips for Diabetic Retinopathy

Story behind

. Story Behind the Approval of FT-003 IND

Training Dynamics

. Move Forward Together

. Let the spirit of learning "take root" in the Finance Department

. Learing about Microbiology

Department Information

. Selection of contract analysis supplier

. A screw--- a story of repairing a shaker

Employee Dynamics

. Anniversary

. Employee Recognition-US

. Star Award Interview-US

Life Sharing

. Food Sharing-Spicy Abalone Chicken

. Tips to Improve Efficiency

. Taihu Lake Riding Edge

Company News Express

US-China Interaction

. CEO's Visit  to US Site

. Learn About Holidays in China and US

. Introduction to Analytical Development Group

Chief Editor        ：    

   

Managing Editor ：   

 

Proofread           ：   

Contributors       ：

Maggie Xue

Jackie Peng

 

Sunny Han

Dianne Brennick , Jiayan He, Jing Yu, Meng Li, Mandy Lu, Qian Wang, Suping Zhao, Tingting Chen, Wan Fang, Yiling Fang, Yiwen Xu, Yolanda Zhao

 On April 12, 2023, Dr. Xinyan Li was invited to attend The 22nd China Biological Products Annual Conference (CBioPC) and chaired the first half of the afternoon discussion of the Cell Therapy and Gene Therapy session on April 13. In this session, Dr. Xinyan Li gave a presentation titlled "Opportunities and Challenges in the development of AAV Gene Therapy Drugs Development".

On April 19, 2023, base on the official website of the Center for Drug Evaluation, NMPA (CDE), the Investigational New Drug (IND) application clinical trial application of AAV gene therapy drug of FT-004 from Frontera Therapeutics was accepted for the indication of hemophilia B (endogenous FIX activity ≤ 2%).

On April 26, 2023, Frontera Therapeutics announced that China CDE accepts Investigational New Drug (IND) application for another gene therapy product, FT-003, for the indication of neovascular age-related macular degeneration (nAMD).

Frontera Therapeutics: AAV gene therapy IND accepted for hemophilia B

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Company News Express

As the company's first Fist-in-class gene therapy drug, FT-002 based on positive pharmacodynamic results and partial clinical safety data from from some IIT subjects, the pre-IND meeting application for FT-002 was submitted successfully on April 27, 2023. FT-002 indication is X-linked retinitis pigmentosa (XLRP).

Frontera Therapeutics Dosed First Patient for Gene Therapy drug candidate FT-003 for the Treatment of Diabetic Macular Edema (DME)

Frontera Therapeutics, a global, clinical-stage biotechnology company that seeks to develop novel and best-in-class gene therapy medicines to improve the lives of patients across multiple disease areas, today announced that it has dosed the first patient at the Ophthalmic Hospital of Tianjin Medical University, China, for its gene therapy program with its gene therapy, FT-003, for the treatment of Diabetic Macular Edema (DME).

DME is a severe retinal disease and is the main cause of vision loss for Diabetic Retinopathy (DR) patients. This represents a major breakthrough, as FT-003 is the first gene therapy product in China advancing into the clinical stage for this indication. FT-003 is, an AAV drug candidate developed independently by Frontera which delivers therapeutic anti-VEGF to the eyes, and is administered by a one-time intravitreal (IVT) injection.

" As an innovative start-up Biotechnology company founded only three years ago, we have established a novel recombinant adeno-associated virus (rAAV) gene therapy drug development technology with our own intellectual property rights, as well as an industrical leading manufacturing platform, and have successfully advanced several programs to clinical stage. This demonstratesd our team’s incredible ability to execute efficiently in developing our pipeline. After initiating a clinical trial in for neovascular age-related macular degeneration (nAMD), we are now taking on the greater challenges of DME, a major cause of blindness in adults, within the hope of bringing in new treatment and opportunies for patients in China and and the rest of the world. ” Dr. Xinyan Li, co-founder and CEO of Frontera Therapeutics, said., "We are committed to providing high-quality, affordable gene therapy products to meet the unmet medical needs of patients with genetic and chronic diseases in China and globally! "

On May 22, 2023, the company's self-developed innovative ophthalmic gene therapy product FT-003 injection successfully completed the administration of the first Diabetic Macular Edema (DME) patient in China at Tianjin Medical University Eye Hospital. It's a Milestone Events of domestic gene therapy drugs in this indication, and also shows the courage of Frontera to overcome difficulties.

FT-003 DME IIT first patient dosed

CEO's Visit to US Site

Learn About Holidays in China and US(May-July)

There are eight of us now! One sentence to describe each of us:

Yiling - team builder and supporter, best manager ever!

Chinmay - Cell based assay expert, CMC lead, everyone’s go-to person whenever there is a question (don’t expect an answer though)

Gina - “Lab Mom”, molecular biology guru, NGS expert, problem solver

Helen - HPLC and MS guru, empty/full analyzer, challenge taker, never-sleep workaholic:)

Linrui - HPLC expert, DNA gel trainer, lab organizer, unofficial company bartender

Michelle - Testing Organizer, expert on all assays, quick learner, soon to be Mrs. Martin

Mullu - the most accurate pipetting champion, baculovirus titer master, cell culture specialist

Justin - HPLC and ddPCR expert, inventory organizer, document czar, “murder” investigator

Introduction to Analytical Development group

QA   xiaowei Cui

 First and foremost, analytical assay development. Our main responsibilities include (but are not limited to) the following：

• Determine phase appropriate analytical method panel

• Develop critical analytical methods, qualify and transfer to QC, and support GMP activities

• Develop key analytical programs including RefStd, formulation, stability, specification, comparability, DP compatibility

• Establish relationship with CROs on programs at various stages

 In the past three years, we have successfully built the AD group and the capabilities of analytical development; including development, optimization and qualification of all analytical assays, supported research and process development, method transfer to QC, managed non-GMP stability studies, and supported IND submission for all the FT 1.0 programs. Our team has also played important role in the rhabdovirus free cell line development work.

Currently we are working on supporting all the FT2.0 programs, optimizing the AAV5 platform, developing new analytical assays for new programs as well as FT1.0 programs late stage development, supporting RD, PD, QC, Clinical, RA and move the programs forward. Look forward to another productive year at Frontera!

Yiling Fang from Analytical Dev.

Our company has recently completed the first dosing of FT-003 for DME (Diabetic Macular Edema), which is certainly another major milestone for our company. But what is diabetic macular edema? To understand diabetic macular edema, we first need to understand DR(Diabetic Retinopathy), because DME can occur at different stages of DR. Today we will focus on diabetic retinopathy.

 Here is an example: Mr. Li is a 40-year-old diabetic patient, diagnosed with type 2 diabetes. His BCVA of the right eye was always around 20/25, but recently his vision suddenly decreased and went to the doctor. Fundus photography showed that his right eye has already progressed to advanced diabetic retinopathy (proliferative diabetic retinopathy) with massive retinal hemorrhage, which needs to be treated with surgery.

Therefore, it is highly recommended that if you or a family member is diagnosed with diabetes, please go to see an ophthalmologist and check the retina regularly to detect the lesion and intervene early and prevent further vision loss.      

Small Tips for Diabetic Retinopathy 

 Hehe Liu from Medical Dept.

    First of all, control of blood glucose, and blood pressure, and timely treatment of eye lesions have an important impact on the prevention and development of diabetic retinopathy. Diabetic retinopathy can develop gradually from non-proliferative to proliferative, and once the transition to proliferative diabetic retinopathy occurs, vitreous hemorrhage and retinal detachment can occur at any time, which can eventually lead to blindness. Macular edema is another common manifestation of diabetic retinopathy, which is one of the important factors leading to severe visual impairment in diabetic patients.

Looking back on this project, two things impressed us most: COVID-19 pandemic caused time-outs in the review of pre-IND and the submission form changed from paper to electronic. 

December 2022 is the most critical time for FT-003 filing while COVID-19 is spreading like wild fire across China. According to our timeline, we would receive CDE  comments for FT-003 pre-IND on December 12, 2022, and after that, we need to respond to CDE comments one by one and revise IND dossier accordingly. We have to submit IND application prior to  January 9, 2023 or the start of phase I clinical trial may be affected. However, almost all CDE staffs were infected by COVID-19 at that time, so FT-003 pre-IND was not reviewed and replied. After dialing CDE’s telephone several times, we found that their telephone was disconnected, we had to give up the call, fell into endless waiting and anxiety, and seeking solutions in WeChat communication groups.

On 26 April 2023, FT-003 Injection obtained the notification of clinical trial.。

Despite a series of challenges during FT-003 IND kick off in March 2022 and IND approval in April 2023, such as Shanghai lockdown, COVID-19 pandemic all over the nation, staff adjustment of the company, and the change of the submission form, we still obtained the notification of clinical trial more than a week earlier than expected (the following figure is the timeline we set in July 2022). 

In addition to the delay of pre-IND response, which would result in the inability to finalize the IND dossier, there is another difficulty: Beijing Express is almost paralyzed due to the COVID-19 pandemic, so our document cannot be successfully mailed to CDE. FT-003 is one of the most valueable projects in our company, and the review progress affects everyone on the team. At the weekly Core meeting team, the U.S. team also helped us finding solutions. Ting Yang (Project Leader) even advised us sending the dossier to reviewer’s home by ourselves. Although this suggestion was not taken, we were moved by everyone's enthusiasm. 

Finally, on January 4, 2023, we received pre-IND responses from CDE, more than 20 days later than we expected!!! At this timepoint, we only have five days left from the scheduled submission date...... what is more challenging is that almost everyone involved in this project has not recovered from COVID-19. The very next day, we pulled the project members to meet, discuss, draft responses, revise IND dossier over and over again,. Finally, it took us only 4 days to finalize all the dossier. 

The last issue before IND filing is the change of submission form. Previously, paper submissions were required, but now the submission form changed into electronic submissions. Although we no longer need to print and bound paper document, there is also a lot of new requirements for electronic submissions, such as "electronic signature" and" signature verification ", which we do for the first time. And since these are new requirements, there is no clear guidelines we can refer to, we have to fumble and operate, trembling to complete the above work, and sent out this valuable CD-ROM documenting the efforts of all the teams with an uneasy heart.

After 60 working days of review by CDE experts, FT-003 Injection IND submission was finally approved. This exciting milestone is mainly due to close cooperations of each department of the company, demonstrating the strong cohesion and excellent executive capability of our team.

Help me up, I can do it!!

CDE telephone is discontinued and can’t get through 

Is the voice in telephone saying “the number you are dialing is out of service”?

Story Behind the Approval of FT-003 IND

Serina from RA and Project Management Dept.

In order to enable DP Prodcution capabilities and Standardize DP opetations,  Suping Zhao from the Production Department DP Section recently conducted a training for colleagues in the production department who will perform the filling operations in the future, which is briefly summarized as the "three key techniques" of formulations.

Operations inside the isolator chamber have big impact on the sterility, foreign objects, and other quality aspects of the product. Therefore, it is not allowed to act upstream of the airflow at the opening of the drug solution and packaging materials. The action should be gentle to avoid interfering with the airflow pattern, and unnecessary actions should be strictly avoided.

Sterile operations should be strictly carried out in accordance with the validated actions, including methods and frequency, to avoid any errors caused by human factors.

It is necessary to continuously strengthen the practice of operational techniques, improve aseptic awareness, precision awareness, enhance business capabilities, strictly inspect and audit, and strive to achieve zero errors and zero errors.

Training is only a short-term professional training, but we also need to improve our regular learning mechanism and form a long-term self-learning and self-checking work and learning style. Training on professional knowledge should follow the principles of "authenticity, accuracy, and systematicity" to clarify the scope, techniques, and steps of equipment operation. Only then can we strive to be the leader and vanguard in work and learning.

The most beautiful April day , We are busy enriching our knowledge. In such a vibrant season，training and learning is like a spring bamboo shoot for the growth and development of our finance ,you can't see its length, but it's growing every day. In order to precipitate knowledge and experience, constantly update the knowledge reserve and promote the construction of a learning organization, the Finance department has continuously carried out several internal training in the department. The theme of this training is "Latest Tax Policy Sharing", Mandy shared the latest tax policy and tax enforcement inspection focus. Through this exchange and learning, everyone had a deeper knowledge and understanding of the tax policies related to enterprises, which provided new ideas for the later tax work. Still water run deep, and learning is endless. Better output comes from having input. We will continue to track the hot knowledge and policies of taxation, and constantly enrich the knowledge structure to provide more value to the company's financial and taxation management and cash management. 

Financial internal knowledge sharing - the latest tax policy

Let the spirit of learning "take root" in the Finance Department

Move Forward Together

Tomato Wang from Production Dept.

Suping is teaching, and the trainees practicing Aseptic Technique

Mandy Lu from Finance Dept.

About microorganisms, easy to understand but hard to usualiz. How can we show the "microscopic world" in a simple and clear way? A professional knowledge sharing from Xiaolong Tang, senior supervisor of microbiology at QC, tried to bring answer to peers.

To visualize invisible bacteria, trainers create their own bacteria until they grow into colonies visible to the naked eye，At the same time, specific pictures are used to show the characteristics of various forms of colonies, so that everyone can have an image cognition of bacteria that are invisible to the naked eye.

图：正在制作细菌样本的培训师

In order to highlight the importance of standardized handwashing in clean areas, the trainer made comparison samples and formed pictures with professional colony counters, objectively and vividly demonstrating the "7-step handwashing method" and the significance of the correct use of disinfectants.

In order to let everyone more vividly understand different types of bacteria such as " coccus, bacilli, mold", the trainer used dyeing identification technology and combined with digital microscope to turn these different types of bacteria into pictures, so that everyone can identify them more intuitively.

To underscore the importance of disciplined behavior in clean areas, the trainer used objective data to illustrate the big impact of some common small actions, Any inconspicuous action can damage the environment of the clean area, remember "Don't assume that things can be done with small disadvantages";

The trainer prepared a variety of materials and samples, which successfully aroused the strong interest of the friends in microorganisms. For daily office life, creating a clean and tidy work area is also one of the important factors to control the growth of microorganisms, so, how long have you not tidied up your workstation? Do it!

Learing about Microbiology

Use staining techniques to create a microscopic examination of the "coccus" sample

 Jiayan He from QC Dept.

 Trainer  preparing a bacterial sample

Guided by objective data to avoid contamination in clean areas

 Correct seven-step handwashing method and macro display of bacterial growth

The evaluation and approval of contracted analysis service supplier is an important part of GxP management, which impact data reliability of registration dossier directly. 16 on-site or remote audits of 11 suppliers have been completed by QA department. By comprehensively evaluation of organizational structure, experimental conditions, instrument management, personnel qualification, training, reagent, reference standard management, analytical records, etc. Total 16 audit reports were completed including nearly one hundred observations. The corrective and preventive actions of the observations will be tracked by CAPA management system. Ensure that all the contracted testing activities comply with GxP regulation. 

Picture:Audit Report

In the biotech industry, cell culture is an important step in manufacturing. In the cell culture process, the shaker is an indispensable and irreplaceable instrument which is of ingenious design, exquisite technology, precise control, and the most important expensive.

One day, the engineering equipment department received a work order from the user to repair a certain brand of shaker, and the description was that the shaker door did not work properly. EE engineer got the notice and did an onsite inspection immediately. At the same time, the engineer also contacted the vendor for more professional support.

  The vendor engineer checked that the equipment software was normal, 

A screw

--- a story of repairing a shaker

 Yoland Zhao from EE Dept.

Picture：Data fo Contract Analysis Supplier

Selection of contract analysis supplier

Xiaowei Cui from QA Dept.

During new instrument installation, we established a good relationship with the shaker vendor. We also solved the shaker bug for their Beijing headquarter. So, when they got informed, they responded immediately. They dispatched an engineer to our Suzhou site for an on-site inspection. The EE engineer and the vendor engineer had a discussion. Both agreed that the malfunction could be caused by the screws loose and mechanical locker malposition. EE engineer tightened the screw, the malfunction got fixed.

On small parts, twist and twist, twist and twist,

A small screw, plays a small role;

On the big structure, twist and twist, twist and twist,

Ann big screws, play a big role;

On particularly large equipment, twist and twist,

Particularly large screws play a particularly large role.

so he disassembled the shaker shell, and after many tests to open and close the door, carefully observed the running path and method, and found that when the door was opened to a certain angle, the air brace instantly produced a very slight deformation, changed the running path, and left a scratch near the left door air brace. Compared with the right door air strut of the same structure, there is no such scratch. The engineer suspected that the cause of the failure was insufficient support for the air strut to prevent the door from opening and closing properly. During this period, the engineers visually found that the center position of the entire structure had a slight offset in the process of opening and closing the door mechanical lock. Compared with the right side, the mechanical lock structure of the entire door is strong and stable, and there is no deformation and flutter during the process of opening and closing the door. Therefore, this doubt was communicated and demonstrated with the brand engineer and the user, and the user felt that the two sides were running differently, which may be the cause of the failure. At this time, the brand engineer removed the air strut for inspection according to the maintenance experience, and found that the 150N air brace engineer could easily press down. The engineer confirmed that the cause of the fault was that the air strut support force was insufficient, resulting in the inability to open and close the door normally, and arranged for the Beijing headquarters to express the air brace spare parts to Suzhou.

After investigations and comparisons, combined with the actual conditions, the emergency escape automatic door was selected. The original function was improved, and the door has following advantages:

Before ---------------------------------- After 

Upgrade main entrance at Suzhou Plant 

Makeover

Xiaoqing Song from EE Dept.

Xiaowei Cui, Jie Hu, Rui Yan, Grant Luo, Yiwen Xu, Betty Zhang, Feng Chen, Qianqian Chen, Jing Yu, Yanli Wu, Yaqin Chu, Likun Yang

Allison Jia, Maggie Xue, Sophie Song, Baochuan Huang, Zhuang Niu, Selina Zhu, Haiwei Zhang, Guangzhi Zhou, Layne Chen, Bennett Wang

It is a pleasure to have you working together and witnessing the growth of each other;

May we all remain steadfast in what we love and spend many more anniversaries;

Bravely climbing the peak of our heart！

Helen Feng 

 

Eric Tang 

Amy Jiang 

Jocelyn Rodriguez 

Dean Falb 

Fading Chen 

Pengcheng Zhou 

Jeff Kan

Chris Casey 

Zhongdong Shi 

Welcome New Collegues

Welcome Yue Zhang from  Clinical Operations Department and Chao Ren from the Translational Medicine Department to join the Frontera family!

We are looking forward to a new journey together!

Employee Recognition-US

Hong Duan recognizing and appreciating her team members: Matthew Ferrer, Brendan Leung and Amy Jiang

Interview with Linrui Li from Analytical Development, who was nominated for Star Award recently:

I joined AD in 2021 after graduating from Northeastern University. This is my first job and I joined when Covid Pandemic was at its peak. The company was still in Newton, the old location.

I joined the company with a background in Bioinformatics. To learn and master these skills takes time and effort. I’m glad I was able to do it. I like fun and challenging stuff.

I like traveling, to see different cities and learn different cultures. I have been to cities like New York, Washington DC, Orlando, Seattle, San Francisco, Los Angeles and cities in Alaska.

Star Award Interview

The hectic pace of life may involve stopping for food, or tasting it, or simply enjoying the process of making it. Today I would like to share with you a dish for all ages: spicy abalone chicken.

INGREDIENTS AND SEASONINGS

Ingredients: 500g chicken drumstick, 12 small abalones, Favorite vegetables (suggested to choose the vegetables is not easy to overcooked, I generally put green beans).

Seasoning: garlic clove, millet pepper, spicy soybean paste, oil consumption, soy sauce, white granulated sugar.

PROCEDURES:

1. Chop the chicken drumstick, wash the abalone that removed shell and gut, peel the garlic cloves, dice the millet pepper, Cut the green beans into sections.

2. Pour 2 spoonful of spicy soy sauce, 1 spoonful of oil, 1 spoonful of dark soy sauce, 1 spoonful of sugar in a small bowl, stir well and set aside.

3. Put the drumsticks in the pot before the water comes to a boil. Skim off the foam when the water comes to a boil.

4. Pour oil Into the pot. When the oil turn to smoke, add garlic stir fry fragrance, put the drumstick block and abalone into the pot. When the drumstick block stir fry to the surface slightly golden, add prepared sauce stir fully, add spicy millet, add the right amount of boiling water (water does not exceed the amount of meat, it is best to join after leaving a peak), Put the green beans into the pot, turn medium fire stew for 30min. After 30min later, add other additional seasonings according to your own taste.

5. Finally turn the heat to collect the juice, and we're done.

MUST NEVER FORGOTEN: Before cooking, Prepared a pot of rice. ;)

Yunuo Zhang form Clinical Operation Dept.

Spicy Abalone Chicken

Food Sharing-Spicy Abalone Chicken

Tips to Improve Efficiency

Do you often fall into the trouble in the picture above? You are expected to complete one task and then the next with ease, but in reality you are often forced to deal with multiple tasks at the same time, and you are suddenly attacked by the ancient tasks left behind by the very procrastination (who is monitoring me?)

How can I get rid of this passive state? How can I handle multiple tasks with ease? How can we say goodbye to "procrastination"?

Here are a few tips to help you improve your work efficiency.

planning is to develop an effective path to achieve the goal;

1. Time is limited, important things to do first.

2. For sure to do things, "strike while the iron is hot and do it immediately".

eg: Meeting minutes immediately organized and sent out after the meeting. Activities immediately after the end of seeking feedback from the participants, to do a review.

 Many times procrastination is due to the fear that the work will need to be "reworked", so the perfectionists always polish long time to delay until the task deadline to deliver, but the demand side will still ask for "rework", and eventually become that "from the A long-ago task that sneaks up on you from behind"

1. Create a sense of "minimum deliverable" and produce the most rudimentary version that you can show to the demand side early on;

2. Seek feedback from the other side, then iterate it to ensure that there is always only one task in hand (more iterations of important things, first iterations of urgent things)

Jackie Peng for HR Dept.

1. Planning has two basic functions: planning and memoing.

2. For sure to do things, "strike while the iron is hot and do it immediately".

eg: Meeting minutes immediately organized and sent out after the meeting. Activities immediately after the end of seeking feedback from the participants, to do a review.

Expected

Me

Task A

Task B&C waiting

Reality

Ancient task that sneaks up on you from behind

Me

Task A&B&C

Receive my love

Success always belongs to those who act now

For long vacation such as Labor Festival and National Festival are popular times for cycling around Taihu Lake, with a cycling mileage of about 270KM and a cycling time of about 14 hours. It's a great challenge for non-professional cyclists. For me, it is not only a physical self-challenge, but also a self-challenge in perseverance.

Road bikes and mountain bikes are recommended as riding tools, of course, as long as you are brave enough to ride a car, you can choose from the bike, but the two-legged 11-way is not recommended! 

When you have a car, you need to be mobile, bring a cycling helmet, gloves, cycling clothes, sun protection, tire repair and full set of tools. Energy supplies, mobile phones and power banks are also essential, and you are ready to go.

Cycling Taihu Lake is a long-distance ride, if you want to ride, you must do your physical reserves and do what you can. A budget with good fitness can be completed in one day, and if you are not fit, then prepare to complete the lake in two days. If you are not in a hurry, it is recommended to complete it in three days, and you can enjoy the beautiful scenery along the way.

Meet cycling enthusiasts on April 29, depart from home at 4:30 a.m., bring energy drinks, chocolate bars, and ride all the way under the guidance of street lights. First ride 60KM to reach the first resting point of Wujiang at about 7:00, which is also the place to eat breakfast, a bowl of stewed meat noodles. Take a short rest, continue to set off, basically rest every 30KM for the whole journey, and arrive home at 7 pm. Plan your rest points and strategies before you go, so you won't be embarrassed during the journey around the lake.

On the road of cycling, every minute is long and torturous, but when you reach the end, you will feel that 270 kilometers is just like that, and it is over in an instant. Beautiful scenery is always on the way.

Taihu Lake Riding Edge

Feng Chen from EE Dept.

Beautiful view around Taihu Lake

Whether it is departmental reunion activities,  industry information, company news, departmental news, science column, or your own growth, life, workplace stories, staff style, parent-child time ... ... are welcome to share!

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